Spironolactone/HCTZ (speer on oh LAK tone; hye droe klor oh THYE a zide) is a combination of 2 diuretics. It helps you make more urine and to lose salt and excess water from your body. It treats swelling from heart, kidney, or liver disease. It also treats high blood pressure. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.