Fluticasone/Salmeterol (floo TIK a sone; sal ME te role) treats asthma and chronic obstructive pulmonary disease (COPD). It works by opening the airways of the lungs, making it easier to breathe. It is a combination of an inhaled steroid and a bronchodilator. It is often called a controller inhaler. Do not use it to treat a sudden asthma attack. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.