Metoclopramide Uses, Brand Names, Side Effects & Interactions

Metoclopramide is a prescription drug used to treat gastroparesis in patients with diabetes. Gastroparesis is a condition which affects spontaneous movements of stomach muscles, making it difficult for food to pass through the intestines. It works to alleviate symptoms of gastroparesis such as nausea, vomiting, and heartburn. In the following 2-minute article, we discuss the uses, brand names, side effects, interactions, and warnings of metoclopramide. 

Metoclopramide Brand Name 

Metoclopramide is available as the following brand name medications:

• Reglan
• Metozolv ODT

It can also be purchased as a generic drug. 

Metoclopramide Uses 

Metoclopramide can be used to treat the symptoms of gastroparesis in diabetic patients. It can also be used to relieve symptoms of other conditions that affect the stomach and intestines. 

Metoclopramide Mechanism Of Action 

Metoclopramide works by increasing movement and contraction in the stomach. It works by blocking messages between the CTZ and the vomiting center. 

Metoclopramide Side Effects

Metoclopramide does have some associated side effects. Some side effects are more serious and less common than others.

Common Side Effects

• Drowsiness
• Headache
• Blistering
• Weakness
• Dizziness
• Diarrhea
• Breast enlargement 
• Missed menstrual period
• Frequent urination
• Inability to control your urination

If these side effects are mild, they may disappear within a few days. If side effects persist, contact your doctor. 

Serious Side Effects

Certain side effects of metoclopramide are more serious. Call your doctor immediately if you experience any of the following serious side effects. Call 9-11 if you think your symptoms may be life-threatening.

• Depression
• Speech problems
• Tightening of stomach muscles
• Sweating
• Restlessness
• Pacing
• Foot tapping
• Rash 
• Hives
• Intense swelling
• Vision problems
• Difficulty breathing or swallowing
• Uncontrollable shaking
• Difficulty staying still
• Challenges with balance 

Disclaimer: At ManifestRX our goal is to provide you with the most relevant and current information. Unfortunately, because drugs affect each individual differently, we cannot guarantee that this information includes all possible side effects.

How To Take Metoclopramide 

Take metoclopramide as directed. This medication can be taken with or without food. Swallow metoclopramide tablets whole with a liquid. For metoclopramide liquid, use the plastic syringe or medicine spoon that comes with your medicine to help you measure out the right dose. If you do not have a medicine spoon, ask your pharmacist for one. 

Metoclopramide Dosage

Metoclopramide dosage can vary depending on the following factors, among others:

• Your age
• Your weight
• Severity of condition 
• Symptoms of diabetes 

Dosage For Diabetic Gastroparesis

Adult: 10 mg four times a day, taken 30 minutes before each meal and at bedtime for 2-8 weeks. Dosage may be adjusted depending on response. 

Dosage For Gastroesophageal Reflux Disease (GERD)

Adult: At first, 10 to 15 milligrams four times a day, taken 30 minutes before symptoms are likely to begin or before each meal and at bedtime, for 4 to 12 weeks. Dosage should not exceed 60mg per day. 

Metoclopramide Warnings

Metoclopramide can make you dizzy and drowsy. Do not drive, use machinery, or do anything that requires alertness immediately after taking metoclopramide. 

This medication can contain aspartame or phenylalanine. If you have phenylketonuria or any other condition that requires you to refrain from consuming aspartame, do not take metoclopramide. 

Interactions Of Metoclopramide  

Metoclopramide may interact with the following medications, among others:

• Antipsychotic drugs such as haloperidol and aripiprazole. 
• Dopamine agonists such as cabergoline, pergolide, and ropinirole. 
• MAO inhibitors such as linezolid, matalaxone, and methylene. 

Metoclopramide Uses, Brand Names, Side Effects & Interactions: Summary

You should take metoclopramide as directed by a healthcare professional. Do not take metoclopramide if you are allergic to aspartame or have phenylketonuria.